Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: GSE135338
INSTRUMENT(S): Q Exactive
ORGANISM(S): Xenopus Laevis (african Clawed Frog)
TISSUE(S): Brain
SUBMITTER: Toshiaki Shigeoka
LAB HEAD: Christine E. Holt
PROVIDER: PXD015650 | Pride | 2019-12-02
REPOSITORIES: Pride
Koppers Max M Cagnetta Roberta R Shigeoka Toshiaki T Wunderlich Lucia Cs LC Vallejo-Ramirez Pedro P Qiaojin Lin Julie J Zhao Sixian S Jakobs Maximilian Ah MA Dwivedy Asha A Minett Michael S MS Bellon Anaïs A Kaminski Clemens F CF Harris William A WA Flanagan John G JG Holt Christine E CE
eLife 20191120
Extrinsic cues trigger the local translation of specific mRNAs in growing axons via cell surface receptors. The coupling of ribosomes to receptors has been proposed as a mechanism linking signals to local translation but it is not known how broadly this mechanism operates, nor whether it can selectively regulate mRNA translation. We report that receptor-ribosome coupling is employed by multiple guidance cue receptors and this interaction is mRNA-dependent. We find that different receptors associ ...[more]