Wnt activator FOXB2 drives the neuroendocrine differentiation of prostate cancer

ABSTRACT: The Wnt signaling pathway is playing a crucial role during development and adult tissue homeostasis. However, the tissue and cell type-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent activator of Wnt signaling in normal and cancer cells. Proximity-dependent biotinylation assay (BioID) coupled with mass spectrometry identified transcriptional co-regulators required for FOXB2-dependent Wnt activation.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Lavanya Moparthi  

LAB HEAD: Dr.Stefan Koch

PROVIDER: PXD015725 | Pride | 2019-10-16

REPOSITORIES: Pride