Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
SUBMITTER: Lavanya Moparthi
LAB HEAD: Dr.Stefan Koch
PROVIDER: PXD015725 | Pride | 2019-10-16
REPOSITORIES: Pride
Moparthi Lavanya L Pizzolato Giulia G Koch Stefan S
Proceedings of the National Academy of Sciences of the United States of America 20191014 44
The Wnt signaling pathway is of paramount importance for development and disease. However, the tissue-specific regulation of Wnt pathway activity remains incompletely understood. Here we identify FOXB2, an uncharacterized forkhead box family transcription factor, as a potent activator of Wnt signaling in normal and cancer cells. Mechanistically, FOXB2 induces multiple Wnt ligands, including WNT7B, which increases TCF/LEF-dependent transcription without activating Wnt coreceptor LRP6 or β-catenin ...[more]