Proteomics

Dataset Information

0

Genome-centric resolution of novel microbial lineages in a Centrosaurus fossil bone from the Late Cretaceous of North America

ABSTRACT: Exceptional preservation of endogenous organics such as collagens and osteocytes has been frequently reported in Mesozoic dinosaur fossils. The persistence of soft tissue in Mesozoic fossil bones has been challenged because of the susceptibility of proteins to degradation and because bone porosity allows microorganisms to colonize the inner microenvironments through geological time. Although protein lability has been studied extensively, the genomic diversity of microbiomes in dinosaur fossil bones and their potential roles in bone diagenesis remain underexplored. Genome-resolved metagenomics and metaproteomics were performed, therefore, on the microbiomes recovered from a Late Cretaceous Centrosaurus bone and its encompassing mudstone that were aseptically excavated in Dinosaur Provincial Park, Alberta, Canada, in order to provide insight into the genomic potential for bone alteration.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Betaproteobacteria Bacterium Rifcsplowo2_02_64_14 Deltaproteobacteria Bacterium Rifcsplowo2_12_full_50_11 Euzebya Tangerina

SUBMITTER: Renxing Liang  

LAB HEAD: Tullis Onstott

PROVIDER: PXD015750 | Pride | 2020-05-27

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Interleukin-10 control of pre-miR155 maturation involves CELF2.

Yoon Jeff S J JSJ   Wu Mike K MK   Zhu Tian Hao TH   Zhao Helen H   Cheung Sylvia T ST   Chamberlain Thomas C TC   Mui Alice L-F AL  

PloS one 20200423 4

The anti-inflammatory cytokine interleukin-10 (IL10) is essential for attenuating inflammatory responses, which includes reducing the expression of pro-inflammatory microRNA-155 (miR155) in lipopolysaccharide (LPS) activated macrophages. miR155 enhances the expression of pro-inflammatory cytokines such as TNFα and suppresses expression of anti-inflammatory molecules such as SHIP1 and SOCS1. We previously found that IL10 interfered with the maturation of pre-miR155 to miR155. To understand the me  ...[more]

Similar Datasets

Proteomics PALEOPROTEOMICS APPLIED TO THE WAZIERS SITE
2023-04-20 | PXD039657 | Pride
Proteomics Robust high throughput proteomics identification and deami-dation quantitation of extinct species up to Pleistocene with Ultrahigh Resolution MALDI-FTICR Mass Spectrometry
2023-04-28 | PXD038283 | Pride
Proteomics A Fossil Protein Chimera; Difficulties in Discriminating Dinosaur Peptide Sequences From Modern Cross-Contamination
2020-04-20 | PXD006360 | Pride
Proteomics Oxidative damage signatures in human bone collagen from Pompeii and Herculaneum.
2021-07-10 | PXD020462 | Pride
Proteomics Extinct species identification from late Middle Pleistocene and earlier Upper Pleistocene bone fragments and tools not recognizable from their osteomorphological study by an enhanced proteomics protocol
2022-06-29 | PXD031386 | Pride
Proteomics,Multiomics Species identification of ancient Lithuanian fish remains using collagen fingerprinting
2018-08-29 | PXD010041 | Pride
Transcriptomics Transcription profiling of mouse protective bones of the skull (parietals), weight-bearing bones of the limb (ulnae), mandibular bone and teeth to obtain basal gene expression levels
2008-11-22 | E-GEOD-13563 | biostudies-arrayexpress
Transcriptomics Gene Expression Profiles of Jaw and Alveolar Bones Are Uniquely Different from Those of Trunk and Limb Bones
2011-06-30 | GSE30167 | GEO
Transcriptomics Twist1-Haploinsufficiency Selectively Enhances the Osteoskeletal Capacity of Mesoderm-derived Parietal Bone through Downregulation of Fgf23
2018-09-15 | GSE119962 | GEO
Proteomics Homo sapiens expanded into the Northern European Plains by 45,000 years ago
2023-10-20 | PXD043272 | Pride