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Proteomics analysis in GGT subjects

ABSTRACT: Proteomic analysis of brain structures derived from GGT subjects

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Tauopathy

SUBMITTER: Enrique SantamarÃa

LAB HEAD: ENRIQUE SANTAMARÍA

PROVIDER: PXD015768 | Pride | 2020-05-26

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	Fracion-No_Phospho_WM6_18-1.wiff	Wiff
	Fracion-No_Phospho_WM6_18-1.wiff.scan	Wiff
	Fracion-No_Phospho_WM6_18-10.wiff	Wiff
	Fracion-No_Phospho_WM6_18-10.wiff.scan	Wiff
	Fracion-No_Phospho_WM6_18-11.wiff	Wiff

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Publications

Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy.

Ferrer Isidro I Andrés-Benito Pol P Zelaya Maria Victoria MV Aguirre Maria Elena Erro MEE Carmona Margarita M Ausín Karina K Lachén-Montes Mercedes M Fernández-Irigoyen Joaquín J Santamaría Enrique E Del Rio José Antonio JA

Acta neuropathologica 20200106 4

Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, oligomeric 4Rtau in neurons and in glial cells forming typical globular astrocyte and oligodendrocyte inclusions (GAIs and GOIs, respectively) and coiled bodies. Present studies centre on four genetic GGT cases from two unrelated families bearing the P301T mutation in MAPT and o ...[more]

PMID: 31907603

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