Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Fibroblast
SUBMITTER: Lukas Krasny
LAB HEAD: Paul Huang
PROVIDER: PXD015816 | Pride | 2021-05-11
REPOSITORIES: Pride
Martinez Victor G VG Pankova Valeriya V Krasny Lukas L Singh Tanya T Makris Spyridon S White Ian J IJ Benjamin Agnesska C AC Dertschnig Simone S Horsnell Harry L HL Kriston-Vizi Janos J Burden Jemima J JJ Huang Paul H PH Tape Christopher J CJ Acton Sophie E SE
Cell reports 20191101 9
Lymph nodes (LNs) act as filters, constantly sampling peripheral cues. This is facilitated by the conduit network, a tubular structure of aligned extracellular matrix (ECM) fibrils ensheathed by fibroblastic reticular cells (FRCs). LNs undergo rapid 3- to 5-fold expansion during adaptive immune responses, but these ECM-rich structures are not permanently damaged. Whether conduit flow or filtering function is affected during LN expansion is unknown. Here, we show that conduits are partially disru ...[more]