Quantitative phosphoproteomics analysis uncovers the regulatory networks of ZNF322A in lung cancer cells

ABSTRACT: Cys2His2 (C2H2)-type zinc finger (ZNF) is one of the most common DNA-binding motif and plays a major role as transcription factors, which encoded by 2% of human genes. C2H2 type ZNFs are reported as proteins of great versatility, such as regulation of differentiation, development, metabolism, cell survival, apoptosis, and autophagy. To uncover ZNF322A-mediated functional network, we applied phosphopeptide enrichment and isobaric labeling strategies with MS-based proteomics, and identified 2754 phosphorylation sites on 976 phosphoproteins.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Lung Cancer

SUBMITTER: Chantal Hoi Yin Cheung  

LAB HEAD: Hsueh-Fen Juan, Ph.D.

PROVIDER: PXD015936 | Pride | 2021-09-08

REPOSITORIES: Pride