Chemical phosphoproteomics reveals kinase network topologies associated to genotypes and phenotypes of cancer cells.

ABSTRACT: We compare the in vitro specificity profiles of several kinase inhibitors with their effects on cellular phosphoproteomes. For this aim, we developed an algorithm which utilizes information on kinase inhibitor selectivity to determine the most probable kinase(s) acting upstream of phosphorylation sites present in phosphoproteomics data obtained from cancer cells treated with kinase inhibitors.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Testis, Myeloblast, Colorectal Cell Line, Peripheral Blood, Epithelial Cell, Breast

DISEASE(S): Acute Myeloid Leukemia,Colorectal Cancer,Embryonal Testis Carcinoma,Breast Cancer

SUBMITTER: Maruan Hijazi  

LAB HEAD: Pedro Cutillas

PROVIDER: PXD015943 | Pride | 2020-01-29

REPOSITORIES: Pride