Proteomics

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Quantitative characterization of the neuropeptide level changes in dorsal horn and dorsal root ganglia regions of the murine itch models

ABSTRACT: In this study, we performed a label-free relative quantitation to identify the peptide candidates correlated with itch sensation in murine models. We tested two different itch models-the AEW model (known commonly as the dry skin model) and the MC903 model. Performed peptide extraction from the dorsal horn (DH) and dorsal root ganglia regions of these two models and compared their levels with that of control mice.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Itching

SUBMITTER: Krishna Anapindi  

LAB HEAD: Jonathan Sweedler

PROVIDER: PXD015949 | Pride | 2020-01-23

REPOSITORIES: Pride

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Quantitative Characterization of the Neuropeptide Level Changes in Dorsal Horn and Dorsal Root Ganglia Regions of the Murine Itch Models.

Tillmaand Emily G EG   Anapindi Krishna D B KDB   De La Toba Eduardo A EA   Guo Changxiong J CJ   Krebs Jessica J   Lenhart Ashley E AE   Liu Qin Q   Sweedler Jonathan V JV  

Journal of proteome research 20200203 3

Chronic itch can be extremely devastating and, in many cases, difficult to treat. One challenge in treating itch disorders is the limited understanding of the multitude of chemical players involved in the communication of itch sensation from the peripheral to the central nervous system. Neuropeptides are intercellular signaling molecules that are known to be involved in the transmission of itch signals from primary afferent neurons, which detect itch in the skin, to higher-order circuits in the  ...[more]

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