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Influenza virus infection leads to global cardiac proteome remodeling during convalescence

ABSTRACT: Influenza virus infection leads to global cardiac proteome remodeling during convalescence MTD project_description "Influenza virus infections lead to more than 500,000 hospitalizations in the U.S. every year. Patients with cardiovascular diseases have been shown to be at high risk of influenza mediated cardiac complications. Importantly, recent reports have provided clinical data supporting a direct link between laboratory-confirmed influenza virus infection and adverse cardiac events. However, the molecular mechanisms of how influenza virus infection induces detrimental cardiac changes, even after resolution of the pulmonary infection, is completely unknown.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Heart

SUBMITTER: Yanbao Yu

LAB HEAD: Yanbao Yu

PROVIDER: PXD015992 | Pride | 2022-04-01

REPOSITORIES: Pride

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Influenza Causes MLKL-Driven Cardiac Proteome Remodeling During Convalescence.

Lin Yi-Han YH Platt Maryann P MP Gilley Ryan P RP Brown David D Dube Peter H PH Yu Yanbao Y Gonzalez-Juarbe Norberto N

Circulation research 20210127 5

<h4>Rationale</h4>Patients with and without cardiovascular diseases have been shown to be at risk of influenza-mediated cardiac complications. Recent clinical reports support the notion of a direct link between laboratory-confirmed influenza virus infections and adverse cardiac events.<h4>Objective</h4>Define the molecular mechanisms underlying influenza virus-induced cardiac pathogenesis after resolution of pulmonary infection and the role of necroptosis in this process.<h4>Methods and results< ...[more]

PMID: 33501852

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Influenza virus infection leads to global cardiac proteome remodeling during convalescence

Project description:Influenza virus infection leads to global cardiac proteome remodeling during convalescence MTD project_description "Influenza virus infections lead to more than 500,000 hospitalizations in the U.S. every year. Patients with cardiovascular diseases have been shown to be at high risk of influenza mediated cardiac complications. Importantly, recent reports have provided clinical data supporting a direct link between laboratory-confirmed influenza virus infection and adverse cardiac events. However, the molecular mechanisms of how influenza virus infection induces detrimental cardiac changes, even after resolution of the pulmonary infection, is completely unknown. We performed global quantitative proteomics as well as phosphoproteomics in this study.

2022-04-04 | PXD016412 | Pride

Streptococcus pneumoniae infection and murine hearat proteome

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Genome-wide analysis of gene expression in influenza A infected human macrophages treated with VX-787

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2023-07-25 | PXD035900 | Pride

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2015-11-05 | PXD002943 | Pride

Phosphoproteomic characterization of Streptococcus pneumoniae and Influenza A virus synergism

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