The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival

ABSTRACT: USP7, as a deubiquitination enzyme, controls ubiquitination and stability of Maf family proteins. USP7 promotes Maf transcriptional activity. Moreover, USP7 is overexpressed in multiple myeloma cells and its expression level is negatively correlated to the survival of myeloma patients.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Multiple Myeloma

SUBMITTER: Jiefei Tong  

LAB HEAD: Mike Moran

PROVIDER: PXD016020 | Pride | 2019-12-16

REPOSITORIES: Pride