Dataset Information
Thermal proteome profiling in Clostridium saccharolyticum
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): [clostridium] Saccharolyticum
SUBMITTER: 
Andre Mateus
LAB HEAD: Kiran Patil
PROVIDER: PXD016064 | Pride | 2021-07-01
REPOSITORIES: Pride
Publications
Bioaccumulation of therapeutic drugs by human gut bacteria.
Nature 20210908 7877
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently<sup>1</sup> and the main underlying mechanism proposed is the chemical transformation of drugs by microorganisms (biotransformation). Here we investigated the depletion of 15 structurally diverse drugs by 25 representative strains of gut bacteria. This revealed 70 bacteria-drug interactions, 29 of which had n ...[more]
