Olfactory proteomics in Dementia with Lewy bodies
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Lewy Body Dementia
SUBMITTER: 
Enrique SantamarÃa
LAB HEAD: ENRIQUE SANTAMARIA
PROVIDER: PXD016069 | Pride | 2021-09-08
REPOSITORIES: Pride
Publications
Proteomic Characterization of the Olfactory Molecular Imbalance in Dementia with Lewy Bodies.
Lachén-Montes Mercedes M Mendizuri Naroa N Schvartz Domitille D Fernández-Irigoyen Joaquín J Sánchez Jean Charles JC Santamaría Enrique E
International journal of molecular sciences 20200902 17
Olfactory dysfunction is one of the prodromal symptoms in dementia with Lewy bodies (DLB). However, the molecular pathogenesis associated with decreased smell function remains largely undeciphered. We generated quantitative proteome maps to detect molecular alterations in olfactory bulbs (OB) derived from DLB subjects compared to neurologically intact controls. A total of 3214 olfactory proteins were quantified, and 99 proteins showed significant alterations in DLB cases. Protein interaction net ...[more]
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