Dataset Information
Thermal proteome profiling in of CA-074me
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Salmonella Typhimurium (strain Lt2 / Sgsc1412 / Atcc 700720) Mus Musculus (mouse)
TISSUE(S): Macrophage
SUBMITTER: 
Andre Mateus
LAB HEAD: Athanasios Typas
PROVIDER: PXD016086 | Pride | 2020-02-07
REPOSITORIES: Pride
Publications
Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection.
Nature microbiology 20200608 9
The interplay between host and pathogen relies heavily on rapid protein synthesis and accurate protein targeting to ensure pathogen destruction. To gain insight into this dynamic interface, we combined Click chemistry with pulsed stable isotope labelling of amino acids in cell culture to quantify the host proteome response during macrophage infection with the intracellular bacterial pathogen Salmonella enterica Typhimurium. We monitored newly synthesized proteins across different host cell compa ...[more]
