Immunopeptidome analysis of 4T1 murine breast cancer cells.

ABSTRACT: This study aimed to identify Tumor Associated Antigens (TAA)s by Immunoaffinity purification of MHC peptides and LCMS analysis, verifying their immunogenicity and testing their tumor control potential in a highly aggressive preclinical model of triple-negative breast cancer in mice. Among the MHC peptides thus identified, an Endogenous Retroviral (ERV) peptide was also found, and this peptide, as well as several other peptides from TAAs, were shown to possess tumor control potential in a cancer vaccine setting in mice, by restricting tumor growth compared to controls.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Breast, Breast Cancer Cell Line, Breast Cancer Cell

DISEASE(S): Breast Cancer

SUBMITTER: Rui Branca  

LAB HEAD: Janne Lehtiö

PROVIDER: PXD016112 | Pride | 2021-09-10

REPOSITORIES: Pride