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Hodgkin lymphoma-educated macrophages

ABSTRACT: Comparative proteome analysis of HL and DLBCL educated human macrophages by SWATH-MS.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Macrophage

DISEASE(S): Lymphoma

SUBMITTER: Katharina Limm

LAB HEAD: Prof. Dr. Peter Oefner

PROVIDER: PXD016128 | Pride | 2020-01-29

REPOSITORIES: Pride

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High CD206 levels in Hodgkin lymphoma-educated macrophages are linked to matrix-remodeling and lymphoma dissemination.

Arlt Annekatrin A von Bonin Frederike F Rehberg Thorsten T Perez-Rubio Paula P Engelmann Julia C JC Limm Katharina K Reinke Sarah S Dullin Christian C Sun Xueni X Specht Rieke R Maulhardt Markus M Linke Franziska F Bunt Gertrude G Klapper Wolfram W Vockerodt Martina M Wilting Jörg J Pukrop Tobias T Dettmer Katja K Gronwald Wolfram W Oefner Peter J PJ Spang Rainer R Kube Dieter D

Molecular oncology 20200128 3

Macrophages (Mφ) are abundantly present in the tumor microenvironment and may predict outcome in solid tumors and defined lymphoma subtypes. Mφ heterogeneity, the mechanisms of their recruitment, and their differentiation into lymphoma-promoting, alternatively activated M2-like phenotypes are still not fully understood. Therefore, further functional studies are required to understand biological mechanisms associated with human tumor-associated Mφ (TAM). Here, we show that the global mRNA express ...[more]

PMID: 31825135

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