Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Toxoplasma Gondii Rh
SUBMITTER: Yohann Couté
LAB HEAD: Virginie Brun
PROVIDER: PXD016133 | Pride | 2020-05-07
REPOSITORIES: Pride
Kloehn Joachim J Oppenheim Rebecca D RD Siddiqui Ghizal G De Bock Pieter-Jan PJ Kumar Dogga Sunil S Coute Yohann Y Hakimi Mohamed-Ali MA Creek Darren J DJ Soldati-Favre Dominique D
BMC biology 20200616 1
<h4>Background</h4>Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enzymes which generate acetyl-CoA in the nucleo-cytosol (acetyl-CoA synthetase (ACS); ATP citrate lyase (ACL)), mitochondrion (branched-chain α-keto acid dehydrogenase-complex (BCKDH)) and apicoplast (pyruvate dehydrogenase complex (PDH)). Given the dive ...[more]