Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos, Q Exactive
ORGANISM(S): Trypanosoma Brucei
SUBMITTER: Thomas Ruppert
LAB HEAD: Thomas Ruppert
PROVIDER: PXD016136 | Pride | 2020-05-27
REPOSITORIES: Pride
PeerJ 20200214
Kinetoplastids rely heavily on post-transcriptional mechanisms for control of gene expression, and on RNA-binding proteins that regulate mRNA splicing, translation and decay. <i>Trypanosoma brucei</i> ERBP1 (Tb927.10.14150) and ERBP2 (Tb927.9.9550) were previously identified as mRNA binding proteins that lack canonical RNA-binding domains. We show here that ERBP1 is associated with the endoplasmic reticulum, like ERBP2, and that the two proteins interact in vivo. Loss of ERBP1 from bloodstream-f ...[more]