Proteomics

Dataset Information

0

MALDI rat liver anticancer drug spiked-in dataset (imzML)

ABSTRACT: For the MALDI-MSI experiment, we selected 12 different drugs. The drugs were purchased from the LC Laboratories (Woburn, MA; CAS numbers: dabrafenib: 1195765-45-7, dasatinib: 302962-49-8, erlotinib: 183321-74-6, gefitinib: 184475-35-2, imatinib: 152459-95-5, lapatinib: 388082-78-8, pazopanib: 444731-52-6, sorafenib: 284461-73-0, sunitinib: 557795-19-4, trametinib: 871700-17-3, vatalanib: 212141-54-3) and from SelleckChem (Munich, Germany; CAS numbers: ipratropium: 60205-81-4) with >99% purity and were dissolved in methanol (MeOH, (Chromasolv Plus for HPLC) (Sigma-Aldrich, Steinheim, Germany) at 10 mg/mL concentration. These stock solutions were further diluted with 50% MeOH and five mixtures were generated, each containing four different drug compounds. The spreadsheet in Supporting Information summarizes the composition of the five drug mixtures. A 5 mg/mL solution of α-cyano-4-hydroxycinnamic acid (CHCA, Sigma-Aldrich) dissolved in 50% MeOH containing 0.1% trifluoroacetic acid (TFA, Sigma-Aldrich, Steinheim, Germany) was used as matrix solution.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: Jonatan Eriksson  

LAB HEAD: Peter Horvatovich

PROVIDER: PXD016146 | Pride | 2019-11-06

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Clusterwise Peak Detection and Filtering Based on Spatial Distribution To Efficiently Mine Mass Spectrometry Imaging Data.

Eriksson Jonatan O JO   Rezeli Melinda M   Hefner Max M   Marko-Varga Gyorgy G   Horvatovich Peter P  

Analytical chemistry 20190823 18

Mass spectrometry imaging (MSI) has the potential to reveal the localization of thousands of biomolecules such as metabolites and lipids in tissue sections. The increase in both mass and spatial resolution of today's instruments brings on considerable challenges in terms of data processing; accurately extracting meaningful signals from the large data sets generated by MSI without losing information that could be clinically relevant is one of the most fundamental tasks of analysis software. Ion i  ...[more]

Similar Datasets

Unknown Expression Profiles of HepG2 cells treated with following compounds: Azathriopine, Furan, Tetradecanoyl phorbol acetate, Tetrachloroethylene, Diazinon and Dmannitol
2015-01-13 | GSE58235 | GEO
Transcriptomics Transcriptomic profiles of white adipose tissue and liver in rats fed either a high-sucrose diet or high-sucrose diet combined with quercetin treatment
2022-09-15 | E-MTAB-11061 | biostudies-arrayexpress
Unknown Expression data of the livers of male C57Bl6/N mice after i.p. injection of paracetamol (APAP)
2021-06-30 | GSE167032 | GEO
Transcriptomics Transcriptomic profiles of white and brown adipose tissue in rats fed either a high-sucrose diet or high-sucrose diet combined with quercetin treatment
2022-10-07 | E-MTAB-11128 | biostudies-arrayexpress
Proteomics MS imaging of tryptic peptides in mouse brain measured at 50 µm pixel size
2018-08-08 | PXD003172 | Pride
Unknown Metformin on human macrophages
2020-06-27 | GSE153318 | GEO
Unknown Effect of LXR agonist T0901317 on the intestinal transcriptome in mice.
2020-10-27 | GSE110528 | GEO
Unknown ATAC-Seq experiment of humanized liver mice with metabolic treatments
2024-01-23 | GSE224277 | GEO
Transcriptomics Human periodontal ligament fibroblasts (PdLFs) were treated with L-lactic acid, a metabolite from periapical granulomas, in comparison to the untreated and positive controls
2023-05-31 | E-MTAB-12932 | biostudies-arrayexpress
Transcriptomics Transcription profiling by array of liver from rats treated with furan to study furan-induced cholangiofibrosis
2008-04-01 | E-MEXP-1421 | biostudies-arrayexpress