Proteomics analysis of the second-generation merozoites of Eimeria tenella under Nitromezuril and Ethanamizuril stress

ABSTRACT: Eimeria tenella is a high pathogenic coccidian that causes avain coccidiosis. Both Nitromezuril(NZL) and Ethanamizuril(EZL) are novel triazine compounds with high anticoccidial activity, but the mechanisms of their action are still unclear. This study explored the response of E.tenella to NZL and EZL by the study of changes in protein composition of the second-generation merozoites using label free quantification proteomics.After drug treatment, the merozoites were analyzed by LC-MS/MS. The identified proteins were annotated and analyzed by Gene ontology, Kyoto Encyclopedia of Genes and Genomes pathway and Protein-protein interaction networks analysis.

INSTRUMENT(S):

ORGANISM(S): Coccidia Eimeria Tenella

TISSUE(S): Cecum, Epithelial Cell

SUBMITTER: 李 雪雁  

LAB HEAD: Fei-qun Xue

PROVIDER: PXD016177 | Pride | 2020-01-09

REPOSITORIES: Pride