Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Eric Fischer
LAB HEAD: Eric Fischer
PROVIDER: PXD016185 | Pride | 2020-11-20
REPOSITORIES: Pride
Słabicki Mikołaj M Yoon Hojong H Koeppel Jonas J Nitsch Lena L Roy Burman Shourya S SS Di Genua Cristina C Donovan Katherine A KA Sperling Adam S AS Hunkeler Moritz M Tsai Jonathan M JM Sharma Rohan R Guirguis Andrew A Zou Charles C Chudasama Priya P Gasser Jessica A JA Miller Peter G PG Scholl Claudia C Fröhling Stefan S Nowak Radosław P RP Fischer Eric S ES Ebert Benjamin L BL
Nature 20201118 7836
Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major pharmacological challenge. The clinical success of thalidomide analogues demonstrates the therapeutic efficacy of drug-induced degradation of transcription factors and other cancer targets<sup>1-3</sup>, but a substantial subset of proteins are resistant to targeted degradation using existing approaches<sup>4,5</sup>. Here we report an alternative mechanism of targeted protein degradation, in which a small m ...[more]