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The examination of Pseudomonas aeruginosa proteome in the presence of phenolic acids

ABSTRACT: Pseudomonas aeruginosa, which is an important oppurtunistic pathogen, is a serious threat for human health, worldwide. New antimicrobial agents are in search and phenolic acids, secondary metabolites of plants, are promising candidates. In this project, the protein profile changes of Pseudomoas aeruginosa were determined after phenolic acid exposure by shot-gun proteomics. It was aimed to enlighten the antimicrobial action mechanism of subinhibitory concentrations of phenolic acids on pathogenic bacteria via proteomic approach.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Escherichia Coli

SUBMITTER: Ozgun Oyku Ozdemir

LAB HEAD: Ferda Soyer Donmez

PROVIDER: PXD016243 | Pride | 2020-08-27

REPOSITORIES: Pride

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<i>Pseudomonas aeruginosa</i> Presents Multiple Vital Changes in Its Proteome in the Presence of 3-Hydroxyphenylacetic Acid, a Promising Antimicrobial Agent.

Ozdemir Ozgun O OO Soyer Ferda F

ACS omega 20200805 32

<i>Pseudomonas aeruginosa</i>, a widely distributed opportunistic pathogen, is an important threat to human health for causing serious infections worldwide. Due to its antibiotic resistance and virulence factors, it is so difficult to combat this bacterium; thus, new antimicrobial agents are in search. 3-Hydroxyphenylacetic acid (3-HPAA), which is a phenolic acid mostly found in olive oil wastewater, can be a promising candidate with its dose-dependent antimicrobial properties. Elucidating the m ...[more]

PMID: 32832748

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