The GTPase Rab39a matures phagosomes into MHC-I antigen-presenting compartments.
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ABSTRACT: We have found Rab39a to be important in dendritic cells to promote antigen crosspresentation. As Rab39a is a Rab GTPase, we sought to determine how it influenced the contents of phagosomes. Thus we used SILAC using Rab39a CRISPR KO or reconstituted cells to determine phagosomal protein differences using a proteomics based approach.
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Dendritic Cell
SUBMITTER: Freidrich Cruz
LAB HEAD: Kenneth Rock
PROVIDER: PXD016394 | Pride | 2019-12-11
REPOSITORIES: Pride
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