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Quantitative proteomic analysis of urine liquid biopsy samples in muscle invasive bladder urothelial carcinoma

ABSTRACT: We performed mass spectrometry-based proteomic analysis of urine samples of patients with BLCA with stroma invasion or muscle invasion to identify prognosis markers for use in liquid-based cytology (LBC).

INSTRUMENT(S): Q Exactive Plus

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine

DISEASE(S): Bladder Transitional Cell Carcinoma

SUBMITTER: Dohyun Han

LAB HEAD: Dohyun Han

PROVIDER: PXD016437 | Pride | 2020-04-29

REPOSITORIES: Pride

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Moesin (MSN) as a Novel Proteome-Based Diagnostic Marker for Early Detection of Invasive Bladder Urothelial Carcinoma in Liquid-Based Cytology.

Park Jeong Hwan JH Lee Cheol C Han Dohyun D Lee Jae Seok JS Lee Kyung Min KM Song Min Ji MJ Kim Kwangsoo K Lee Heonyi H Moon Kyung Chul KC Kim Youngsoo Y Jung Minsun M Moon Ji Hye JH Lee Hyebin H Ryu Han Suk HS

Cancers 20200421 4

Bladder urothelial carcinoma (BUC) is the most lethal malignancy of the urinary tract. Treatment for the disease highly depends on the invasiveness of cancer cells. Therefore, a predictive biomarker needs to be identified for invasive BUC. In this study, we employed proteomics methods on urine liquid-based cytology (LBC) samples and a BUC cell line library to determine a novel predictive biomarker for invasive BUC. Furthermore, an in vitro three-dimensional (3D) invasion study for biological sig ...[more]

PMID: 32326232

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