Proteomics

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Data Set: Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D

ABSTRACT: RAW files of corresponding Baits used in Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D

INSTRUMENT(S): LTQ Orbitrap, LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: Mohamed Ali Jarboui  

LAB HEAD: mohamed ali jarboui

PROVIDER: PXD016464 | Pride | 2019-12-04

REPOSITORIES: Pride

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Publications

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS<sup>G13D</sup>.

Kennedy Susan A SA   Jarboui Mohamed-Ali MA   Srihari Sriganesh S   Raso Cinzia C   Bryan Kenneth K   Dernayka Layal L   Charitou Theodosia T   Bernal-Llinares Manuel M   Herrera-Montavez Carlos C   Krstic Aleksandar A   Matallanas David D   Kotlyar Max M   Jurisica Igor I   Curak Jasna J   Wong Victoria V   Stagljar Igor I   LeBihan Thierry T   Imrie Lisa L   Pillai Priyanka P   Lynn Miriam A MA   Fasterius Erik E   Al-Khalili Szigyarto Cristina C   Breen James J   Kiel Christina C   Serrano Luis L   Rauch Nora N   Rukhlenko Oleksii O   Kholodenko Boris N BN   Iglesias-Martinez Luis F LF   Ryan Colm J CJ   Pilkington Ruth R   Cammareri Patrizia P   Sansom Owen O   Shave Steven S   Auer Manfred M   Horn Nicola N   Klose Franziska F   Ueffing Marius M   Boldt Karsten K   Lynn David J DJ   Kolch Walter W  

Nature communications 20200124 1

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS<sup>G13D</sup>) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is extensively rewired in cells expressing tran  ...[more]

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