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Human liver cancer Phosphoproteomics

ABSTRACT: Effect of Aminopeptidase N on Hepatocellular Carcinoma

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hepatocyte, Liver

SUBMITTER: mengying zhai

LAB HEAD: Mengying Zhai

PROVIDER: PXD016468 | Pride | 2021-09-09

REPOSITORIES: Pride

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Publications

APN-mediated phosphorylation of BCKDK promotes hepatocellular carcinoma metastasis and proliferation via the ERK signaling pathway.

Zhai Mengying M Yang Zixia Z Zhang Chenrui C Li Jinping J Jia Jing J Zhou Lingyi L Lu Rong R Yao Zhi Z Fu Zheng Z

Cell death & disease 20200526 5

Hepatocellular carcinoma (HCC) is one of the most prevalent human malignancies worldwide and has high morbidity and mortality. Elucidating the molecular mechanisms underlying HCC recurrence and metastasis is critical to identify new therapeutic targets. This study aimed to determine the roles of aminopeptidase N (APN, also known as CD13) in HCC proliferation and metastasis and its underlying mechanisms. We detected APN expression in clinical samples and HCC cell lines using immunohistochemistry, ...[more]

PMID: 32457292

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