Proteomics on colorectal cancer MCTS upon OXPHOS inhibition

ABSTRACT: Previous high throughput gene expression profiling combined with a HCT116 colon cancer tumor spheroid-based drug-screening assay identified context-dependent treatment responses to OXPHOS inhibitors resulting in a shunting towards the mevalonate pathway. To complement these findings with a characterization of the proteome we use mass-spectrometry based proteomics to investigate protein profiles and context-dependent treatment responses in PMCTS and QMCTS compared to monolayer cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: Julia Steinmetz  

LAB HEAD: Kim Kultima

PROVIDER: PXD016495 | Pride | 2020-07-29

REPOSITORIES: Pride