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Mouse Brain LC-MSMS. To identify the heterogeneity of aBLA and pBLA.

ABSTRACT: To identify the heterogeneity of aBLA and pBLA at protein level, TMT labeled-Quantitative Proteomics strategy was applied.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Ying Yang

LAB HEAD: Ying Yang

PROVIDER: PXD016515 | Pride | 2020-05-27

REPOSITORIES: Pride

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Publications

Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect.

Pi Guilin G Gao Di D Wu Dongqin D Wang Yali Y Lei Huiyang H Zeng Wenbo W Gao Yang Y Yu Huiling H Xiong Rui R Jiang Tao T Li Shihong S Wang Xin X Guo Jing J Zhang Si S Yin Taoyuan T He Ting T Ke Dan D Li Ruining R Li Honglian H Liu Gongping G Yang Xifei X Luo Min-Hua MH Zhang Xiaohui X Yang Ying Y Wang Jian-Zhi JZ

Nature communications 20200110 1

The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly and functionally diverse along their anterior-posterior and superficial-deep axes. Here, we find that anterior BLA (aBLA) and posterior BLA (pBLA) innervate deep-layer calbindin1-negative (Calb1-) and superficial-layer calbindin1-positive neurons (Calb1+) in vCA1, respectively. Photostimulation of pBLA-vCA1 inputs has an anxiolytic effect in mice, promoting approach behaviours during conflict exploratory tasks. By c ...[more]

PMID: 31924799

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