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Analysis of EYA3 phosphorylation by Src kinase

ABSTRACT: Data-dependent nLC-MS/MS analysis of EYA3 phosphorylation by Src protein tyrosine kinase

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Aura Elena Ionescu

LAB HEAD: Stefan Eugen Szedlacsek

PROVIDER: PXD016518 | Pride | 2019-12-17

REPOSITORIES: Pride

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Analysis of EYA3 Phosphorylation by Src Kinase Identifies Residues Involved in Cell Proliferation.

Ionescu Aura E AE Mentel Mihaela M Munteanu Cristian V A CVA Sima Livia E LE Martin Eliza C EC Necula-Petrareanu Georgiana G Szedlacsek Stefan E SE

International journal of molecular sciences 20191213 24

Eyes absent (EYA) are non-thiol-based protein tyrosine phosphatases (PTPs) that also have transcriptional co-activator functions. Their PTP activity is involved in various pathologies. Recently, we demonstrated that Src tyrosine kinase phosphorylates human EYA3 by controlling its subcellular localization. We also found EYA3's ability to autodephosphorylate, while raising the question if the two opposing processes could be involved in maintaining a physiologically adequate level of phosphorylatio ...[more]

PMID: 31847183

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