Extensive Rewiring of the EGFR Network in Colorectal Cancer Cells Expressing Transforming Levels of KRASG13D
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Colon Cancer
SUBMITTER: 
Mohamed Ali Jarboui
LAB HEAD: Mohamed ali Jarboui
PROVIDER: PXD016549 | Pride | 2019-12-03
REPOSITORIES: Pride
Publications
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS<sup>G13D</sup>.
Kennedy Susan A SA Jarboui Mohamed-Ali MA Srihari Sriganesh S Raso Cinzia C Bryan Kenneth K Dernayka Layal L Charitou Theodosia T Bernal-Llinares Manuel M Herrera-Montavez Carlos C Krstic Aleksandar A Matallanas David D Kotlyar Max M Jurisica Igor I Curak Jasna J Wong Victoria V Stagljar Igor I LeBihan Thierry T Imrie Lisa L Pillai Priyanka P Lynn Miriam A MA Fasterius Erik E Al-Khalili Szigyarto Cristina C Breen James J Kiel Christina C Serrano Luis L Rauch Nora N Rukhlenko Oleksii O Kholodenko Boris N BN Iglesias-Martinez Luis F LF Ryan Colm J CJ Pilkington Ruth R Cammareri Patrizia P Sansom Owen O Shave Steven S Auer Manfred M Horn Nicola N Klose Franziska F Ueffing Marius M Boldt Karsten K Lynn David J DJ Kolch Walter W
Nature communications 20200124 1
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS<sup>G13D</sup>) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is extensively rewired in cells expressing tran ...[more]
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