HHIP-AS1 lncRNA promotes tumorigenicity in human SHH-driven brain tumors

ABSTRACT: Long non-coding RNAs (lncRNAs) comprise a diverse class of gene expression regulators with emerging roles in many biological processes including cancer. Here we show that the expression of the lncRNA Hedgehog Interacting Protein Antisense 1 (HHIP-AS1) is a hallmark feature of human SHH-driven tumors. Importantly, loss of HHIP-AS1 leads to reduced tumor growth in SHH-driven tumors in vitro and in vivo. Our results demonstrate the power of cross-entity transcriptome-wide comparisons to identify novel epigenetic–regulatory lncRNA circuitries underlying human cancers.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Medulloblastoma

SUBMITTER: Nina Overbeck  

LAB HEAD: Kai Stühler

PROVIDER: PXD016550 | Pride | 2022-06-01

REPOSITORIES: Pride