Proteomic Signature of Nucleus Pulposus of Human Intervertebral Disc

ABSTRACT: Intervertebral Disc (IVD) degeneration leading to Low back pain (LBP) is the most common musculoskeletal disorder. Lack of knowledge on the intricate homeostatic mechanisms necessitates proteomic characterisation of a normal human IVD to understand the biological process and unravel the pathomechanisms of degenerative disc disease (DDD). In this study, we employed proteomic approach coupled with tandem mass-spectrometry to derive the comprehensive list of proteins expressed in true biologically normal control discs. This would serve as the basis for identifying the interacting molecules participating in significant biological processes and pathways disrupted during aging and degeneration.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Chondrocyte, Nucleus Pulposus

DISEASE(S): Degenerative Disc Disease

SUBMITTER: Chitraa Tangavel  

LAB HEAD: Chitraa Tangavel

PROVIDER: PXD016560 | Pride | 2021-09-09

REPOSITORIES: Pride