Extracellular vesicles from Notch activated cardiac mesenchymal stem cell promote myocyte proliferation and neo-vasculogenesis

ABSTRACT: Cardiac mesenchymal stem cells (C-MSC) are a novel mesenchymal stem cell subpopulation derived from cardiac tissue, whichi are reported to be responsible for cardiac regeneration. Notch siganling is believed to aid in cardiac repair following myocardial injury.Here, we investigated the difference of protein cargo content among extracellular vesicles from wild type C-MSC, Notch1 knock out C-MSC and Notch1 activated C-MSC.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Mesenchymal Cell

SUBMITTER: Wanling Xuan  

LAB HEAD: Muhammad Ashraf

PROVIDER: PXD016578 | Pride | 2020-05-27

REPOSITORIES: pride