Proteomics

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Extracellular vesicles from Notch activated cardiac mesenchymal stem cell promote myocyte proliferation and neo-vasculogenesis


ABSTRACT: Cardiac mesenchymal stem cells (C-MSC) are a novel mesenchymal stem cell subpopulation derived from cardiac tissue, whichi are reported to be responsible for cardiac regeneration. Notch siganling is believed to aid in cardiac repair following myocardial injury.Here, we investigated the difference of protein cargo content among extracellular vesicles from wild type C-MSC, Notch1 knock out C-MSC and Notch1 activated C-MSC.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Mesenchymal Cell

SUBMITTER: Wanling Xuan  

LAB HEAD: Muhammad Ashraf

PROVIDER: PXD016578 | Pride | 2020-05-27

REPOSITORIES: Pride

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Extracellular Vesicles From Notch Activated Cardiac Mesenchymal Stem Cells Promote Myocyte Proliferation and Neovasculogenesis.

Xuan Wanling W   Khan Mahmood M   Ashraf Muhammad M  

Frontiers in cell and developmental biology 20200221


Cardiac mesenchymal stem cells (C-MSCs) are a novel mesenchymal stem cell (MSC) subpopulation derived from cardiac tissue, which are reported to be responsible for cardiac regeneration. Notch signaling is believed to aid in cardiac repair following myocardial injury. In this study, we have investigated the role of extracellular vesicles (EVs) from Notch1 engineered C-MSCs on angiogenesis and cardiomyocyte (CM) proliferation in ischemic myocardium. C-MSCs were isolated from Notch1<sup>flox</sup>  ...[more]

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