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Proteomic data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity

ABSTRACT: proteomic data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Liver

SUBMITTER: mingshuang wang

LAB HEAD: mingshuang wang

PROVIDER: PXD016625 | Pride | 2020-05-27

REPOSITORIES: Pride

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Integrative analysis of proteomic and metabonomics data for identification of pathways related to Rhizoma Paridis-induced hepatotoxicity.

Zhao Chongjun C Wang Mingshuang M Huang Jianmei J Jia Zhe Z Zhao Xia X Li Erwen E Wei Ziying Z Dong Ying Y Liu Wenxue W Han Ting T Liu Ying Y Li Farong F Lin Ruichao R

Scientific reports 20200416 1

Clinical reports on hepatotoxicity that arise from Rhizoma Paridis have recently received widespread attention. Because the hepatotoxicity mechanism is little understood, this research strived to investigate the hepatotoxicity mechanism of Rhizoma Paridis extracts based on iTRAQ quantitative proteomics and metabonomics. The extraction solutions were administrated to rats for 7 days by gavage, and the hepatotoxicity was assessed through quantification of biochemical indexes and Oil red O staining ...[more]

PMID: 32300172

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