Protein Pathways in Controls vs Progressive and NonProgressive Pulmonary Sarcoidosis
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
DISEASE(S): Pulmonary Sarcoidosis
SUBMITTER: 
Kevin Viken
LAB HEAD: Maneesh Bhargava, MD, PhD
PROVIDER: PXD016637 | Pride | 2021-09-09
REPOSITORIES: Pride
Publications
Novel protein pathways in development and progression of pulmonary sarcoidosis.
Bhargava Maneesh M Viken K J KJ Barkes B B Griffin T J TJ Gillespie M M Jagtap P D PD Sajulga R R Peterson E J EJ Dincer H E HE Li L L Restrepo C I CI O'Connor B P BP Fingerlin T E TE Perlman D M DM Maier L A LA
Scientific reports 20200806 1
Pulmonary involvement occurs in up to 95% of sarcoidosis cases. In this pilot study, we examine lung compartment-specific protein expression to identify pathways linked to development and progression of pulmonary sarcoidosis. We characterized bronchoalveolar lavage (BAL) cells and fluid (BALF) proteins in recently diagnosed sarcoidosis cases. We identified 4,306 proteins in BAL cells, of which 272 proteins were differentially expressed in sarcoidosis compared to controls. These proteins map to n ...[more]
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