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SHANK2A and SHANK2A(R841X) mouse brain SWATH quantitative proteomics

ABSTRACT: The high molecular complexity of the SHANK scaffold and its fundamental role in neural circuitries governing social behavior is not well understood. Here we analyzed two newly generated transgenic mouse lines with the SHANK2A wild-type isoform and the other with SHANK2A carrying a SHANK2A(R841X) point mutation. The proteome of hippocampal synapse-enriched fraction for both lines was investigated by quantitative SWATH proteomic analysis in order to identify synaptic proteins and signaling pathways that respond to the SHANK2 isoforms.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Miguel A. Gonzalez-Lozano

LAB HEAD: Ka Wan Li

PROVIDER: PXD016665 | Pride | 2022-02-23

REPOSITORIES: Pride

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			Action	DRS
	20180619_Shank_HipP2_01_731.wiff	Wiff
	20180619_Shank_HipP2_01_731.wiff.scan	Wiff
	20180619_Shank_HipP2_02_734.wiff	Wiff
	20180619_Shank_HipP2_02_734.wiff.scan	Wiff
	20180619_Shank_HipP2_03_735.wiff	Wiff

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