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Potential ATF6 regulatory proteins were screened by proteomics using pancreatic tissues of PRSS1 transgenic mice treated with caerulein

ABSTRACT: Humanized PRSS1 transgenic mice were constructed and treated with caerulein to mimic the development of human AP and CP. Potential ATF6 regulatory proteins in pancreatitis were screened by proteomics using pancreatic tissues of PRSS1 AP mice.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreas

DISEASE(S): Pancreatitis

SUBMITTER: Zhang guowei

LAB HEAD: Guo-wei Zhang

PROVIDER: PXD016703 | Pride | 2021-09-09

REPOSITORIES: Pride

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ATF6 aggravates acinar cell apoptosis and injury by regulating p53/AIFM2 transcription in Severe Acute Pancreatitis.

Tan Jie-Hui JH Cao Rong-Chang RC Zhou Lei L Zhou Zhi-Tao ZT Chen Huo-Ji HJ Xu Jia J Chen Xue-Mei XM Jin Yang-Chen YC Lin Jia-Yu JY Zeng Jun-Ling JL Li Shu-Ji SJ Luo Min M Hu Guo-Dong GD Yang Xiao-Bing XB Jin Jin J Zhang Guo-Wei GW

Theranostics 20200709 18

<b>Background:</b> There is no curative therapy for severe acute pancreatitis (SAP) due to poor understanding of its molecular mechanisms. Endoplasmic reticulum (ER) stress is involved in SAP and increased expression of ATF6 has been detected in SAP patients. Here, we aimed to investigate the role of ATF6 in a preclinical SAP mouse model and characterize its regulatory mechanism. <b>Methods:</b> Pancreatic tissues of healthy and SAP patients were collected during surgery. Humanized PRSS1 transge ...[more]

PMID: 32724472

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