Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Kidney
SUBMITTER: SEYOUNG YU
LAB HEAD: Heon Yung Gee
PROVIDER: PXD016725 | Pride | 2021-09-09
REPOSITORIES: Pride
Journal of the American Society of Nephrology : JASN 20200507 6
<h4>Background</h4>Mutations in <i>ADCK4</i> (aarF domain containing kinase 4) generally manifest as steroid-resistant nephrotic syndrome and induce coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) deficiency. However, the molecular mechanisms underlying steroid-resistant nephrotic syndrome resulting from <i>ADCK4</i> mutations are not well understood, largely because the function of ADCK4 remains unknown.<h4>Methods</h4>To elucidate the ADCK4's function in podocytes, we generated a podocyte-specific, ...[more]