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Grape leaves polyphenols inhibit breast cancer malignancy

ABSTRACT: We tested the inhibitory effects of hydroalcoholic extracts from grape leaves in breast cancer malignancy using MCF-7 and SKBR-3 cell lines.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Breast Cancer

SUBMITTER: maria tomasi

LAB HEAD: Maria Lauda Tomasi

PROVIDER: PXD016748 | Pride | 2020-05-27

REPOSITORIES: Pride

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SUMOylation Protects FASN Against Proteasomal Degradation in Breast Cancer Cells Treated with Grape Leaf Extract.

Floris Andrea A Mazarei Michael M Yang Xi X Robinson Aaron Elias AE Zhou Jennifer J Barberis Antonio A D'hallewin Guy G Azara Emanuela E Spissu Ylenia Y Iglesias-Ara Ainhoa A Orrù Sandro S Tomasi Maria Lauda ML

Biomolecules 20200331 4

Existing therapeutic strategies for breast cancer are limited by tumor recurrence and drug-resistance. Antioxidant plant-derived compounds such as flavonoids reduce adverse outcomes and have been identified as a potential source of antineoplastic agent with less undesirable side effects. Here, we describe the novel regulation of fatty-acid synthase (FASN), the key enzyme in de novo fatty-acid synthesis, whereby <i>Vitis vinifera</i> L. cv Vermentino leaf hydroalcoholic extract lowers its protein ...[more]

PMID: 32244364

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