Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): B Cell, Cell Suspension Culture, Cell Culture
DISEASE(S): Acute Leukemia
SUBMITTER: Matthew Nix
LAB HEAD: Arun Wiita
PROVIDER: PXD016800 | Pride | 2022-02-15
REPOSITORIES: Pride
Nix Matthew A MA Mandal Kamal K Geng Huimin H Paranjape Neha N Lin Yu-Hsiu T YT Rivera Jose M JM Marcoulis Makeba M White Kristie L KL Whitman Jeffrey D JD Bapat Sagar P SP Parker Kevin R KR Ramirez Jonathan J Deucher Anne A Phojanokong Paul P Steri Veronica V Fattahi Faranak F Hann Byron C BC Satpathy Ansuman T AT Manglik Aashish A Stieglitz Elliot E Wiita Arun P AP
Cancer discovery 20210316 8
Alternative strategies are needed for patients with B-cell malignancy relapsing after CD19-targeted immunotherapy. Here, cell surface proteomics revealed CD72 as an optimal target for poor-prognosis <i>KMT2A</i>/<i>MLL1</i>-rearranged (MLLr) B-cell acute lymphoblastic leukemia (B-ALL), which we further found to be expressed in other B-cell malignancies. Using a recently described, fully <i>in vitro</i> system, we selected synthetic CD72-specific nanobodies, incorporated them into chimeric antige ...[more]