Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Eduard Sabidó
LAB HEAD: Amy Curwin
PROVIDER: PXD016815 | Pride | 2020-03-26
REPOSITORIES: Pride
Cruz-Garcia David D Brouwers Nathalie N Malhotra Vivek V Curwin Amy J AJ
The Journal of cell biology 20200401 4
Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other antioxidant enzymes such as thioredoxins (Trx1 and Trx2) and peroxiredoxin Ahp1 in a Grh1-dependent manner. Our data reveal that starvation leads to production of nontoxic levels of reactive oxygen species (ROS). Treatment of cells with N-acetylcysteine (NAC), which sequesters ROS, p ...[more]