Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell, Cell Culture
DISEASE(S): Malignant Neoplasm Of Ovary
SUBMITTER: Di HU
LAB HEAD: Chi-Ming Che
PROVIDER: PXD016875 | Pride | 2021-09-08
REPOSITORIES: Pride
Proceedings of the National Academy of Sciences of the United States of America 20200102 3
Cysteine thiols of many cancer-associated proteins are attractive targets of anticancer agents. Herein, we unequivocally demonstrate a distinct thiol-targeting property of gold(III) mesoporphyrin IX dimethyl ester (AuMesoIX) and its anticancer activities. While the binding of cysteine thiols with metal complexes usually occurs via M-S bond formation, AuMesoIX is unique in that the <i>meso</i>-carbon atom of the porphyrin ring is activated by the gold(III) ion to undergo nucleophilic aromatic sub ...[more]