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Integrative membrane proteome analysis of High and Low-metastatic Lung Cancers

ABSTRACT: Membrane proteins play critical roles between the tumor cells and the extra-cellular matrix (ECM) during metastasis. In this study, we performed quantitative proteomic analysis of membrane proteins from two human giant-cell lung carcinoma cell strains, low- (95C) and high-(95D) metastatistic cell lines, and combining with microRNA analysis, we identified a multi-omics regulation module.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Lung, Cell Culture

SUBMITTER: Yan Kong

LAB HEAD: Hui Lu

PROVIDER: PXD016912 | Pride | 2020-08-18

REPOSITORIES: Pride

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Integrative Analysis of Membrane Proteome and MicroRNA Reveals Novel Lung Cancer Metastasis Biomarkers.

Kong Yan Y Qiao Zhi Z Ren Yongyong Y Genchev Georgi Z GZ Ge Maolin M Xiao Hua H Zhao Hongyu H Lu Hui H

Frontiers in genetics 20200828

Lung cancer is one of the most common human cancers both in incidence and mortality, with prognosis particularly poor in metastatic cases. Metastasis in lung cancer is a multifarious process driven by a complex regulatory landscape involving many mechanisms, genes, and proteins. Membrane proteins play a crucial role in the metastatic journey both inside tumor cells and the extra-cellular matrix and are a viable area of research focus with the potential to uncover biomarkers and drug targets. In ...[more]

PMID: 33005184

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