Dataset Information
Human Endothelial Cell Secretome
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Endothelial Cell Of Umbilical Vein, Cell Culture
SUBMITTER: 
KOJI IKEDA
LAB HEAD: Koji Ikeda
PROVIDER: PXD016932 | Pride | 2020-01-29
REPOSITORIES: Pride
Publications
Endothelial progeria induces adipose tissue senescence and impairs insulin sensitivity through senescence associated secretory phenotype.
Nature communications 20200124 1
Vascular senescence is thought to play a crucial role in an ageing-associated decline of organ functions; however, whether vascular senescence is causally implicated in age-related disease remains unclear. Here we show that endothelial cell (EC) senescence induces metabolic disorders through the senescence-associated secretory phenotype. Senescence-messaging secretomes from senescent ECs induced a senescence-like state and reduced insulin receptor substrate-1 in adipocytes, which thereby impaire ...[more]
