A Quantitative Proteome Map of the Human Body

ABSTRACT: In this study, we quantified the relative protein levels from 12,627 genes across 32 normal human tissue types prepared by the GTEx project. Known and new tissue specific or enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode highly tissue specific proteins. Discordance in the sites of RNA expression and protein detection also revealed potential sites of synthesis and action of protein signaling molecules. Overall, these results provide an extraordinary resource, and demonstrate that understanding protein levels can provide insights into metabolism, regulation, secretome, and human diseases.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Testis, Heart, Spleen, Stomach, Brain, Skeletal Muscle, Liver, Lung, Thyroid Gland, Artery, Esophagus, Ovary, Skin, Colon, Saliva, Small Intestine

SUBMITTER: Lihua Jiang  

LAB HEAD: mike snyder

PROVIDER: PXD016999 | Pride | 2020-11-16

REPOSITORIES: Pride