Proteomics

Dataset Information

0

HO-1/BMMSCs exosomes treating inflammatory injured IEC-6 cells LC-MSMS


ABSTRACT: In this study, we established a rat small intestinal cell (IEC-6) injury model with tumor necrosis factor-α (TNF-α). Then, we added the exosomes from TNF- α damaged IEC-6 (TNF-α-exo), co-cultured with BMMSCs exosomes (BM-exo) and heme oxygenase-1 modified BMMSCs (HBM-exo) system exosomes into IEC-6 cells injured by TNF- α inflammation. After 48 hours, IEC-6 cells were collected for proteomic detection.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Cell Culture, Intestinal Epithelial Cell

SUBMITTER: Sun Dong  

LAB HEAD: Dong Sun

PROVIDER: PXD017002 | Pride | 2020-06-29

REPOSITORIES: Pride

altmetric image

Publications

MiR-200b in heme oxygenase-1-modified bone marrow mesenchymal stem cell-derived exosomes alleviates inflammatory injury of intestinal epithelial cells by targeting high mobility group box 3.

Sun Dong D   Cao Huan H   Yang Liu L   Lin Ling L   Hou Bin B   Zheng Weiping W   Shen Zhongyang Z   Song Hongli H  

Cell death & disease 20200625 6


Heme Oxygen-1 (HO-1)-modified bone marrow mesenchymal stem cells (BMMSCs) are effective to protect and repair transplanted small bowel and intestinal epithelial cells (IECs); however, the mechanism and the role of HO-1/BMMSCs-derived exosomes is unclear. In the present study, we aimed to verify that exosomes from a HO-1/BMMSCs and IEC-6 cells (IEC-6s) co-culture system could reduce the apoptosis of IEC-6s and decrease the expression of the tight junction protein, zona occludens 1, in the inflamm  ...[more]

Similar Datasets

2023-08-20 | PXD041547 | Pride
2024-01-13 | PXD047542 | Pride
2021-03-23 | PXD022641 | Pride
2021-03-18 | PXD021144 | Pride
2021-09-09 | PXD022558 | Pride
2020-08-06 | GSE155745 | GEO
| E-GEOD-60003 | biostudies-arrayexpress
| E-GEOD-54785 | biostudies-arrayexpress
| E-GEOD-70700 | biostudies-arrayexpress
| E-GEOD-68984 | biostudies-arrayexpress