Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Pang-Hung Hsu
LAB HEAD: Pang-Hung Hsu
PROVIDER: PXD017046 | Pride | 2021-01-25
REPOSITORIES: Pride
Su Fang-Yi FY Huang Shih-Chia SC Wei Pei-Chi PC Hsu Pang-Hung PH Li Ju-Pi JP Su Li-Wen LW Hsieh Yung-Lin YL Hu Chun-Mei CM Hsu Jye-Lin JL Yang Cheng-Yuan CY Chung Chen-Yen CY Shew Jin-Yuh JY Lan Joung-Liang JL Sytwu Huey-Kang HK Lee Eva Y-Hp EY Lee Wen-Hwa WH
Free radical biology & medicine 20210116
Emerging evidences implicate the contribution of ROS to T cell activation and signaling. The tyrosine kinase, ζ-chain-associated protein of 70 kDa (ZAP70), is essential for T cell development and activation. However, it remains elusive whether a direct redox regulation affects ZAP70 activity upon TCR stimulation. Here, we show that deficiency of non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx), a redox sensor, results in T cell hyperproliferation and elevat ...[more]