Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, AB SCIEX instrument model
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Blood Plasma
DISEASE(S): Lung Non-squamous Non-small Cell Carcinoma
SUBMITTER: Theo Platt
LAB HEAD: John Blume
PROVIDER: PXD017052 | Pride | 2020-08-12
REPOSITORIES: Pride
Nature communications 20200722 1
Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma proteome. Here we report a highly parallel protein quantitation platform integrating nanoparticle (NP) protein coronas with liquid chromatography-mass spectrometry for efficient proteomic profiling. A protein corona is a protein layer adsorbed onto NPs upon contact with biofluids. Varying the physicochemical properties of engineered NPs translates to distinct protein corona patterns enabling differential and ...[more]