Dataset Information
Tau posttranslational modifications
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Velos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Alzheimer's Disease
SUBMITTER: 
Dagmar Ehrnhoefer
LAB HEAD: Dagmar E. Ehrnhoefer
PROVIDER: PXD017065 | Pride | 2021-09-09
REPOSITORIES: Pride
Publications
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Molecular neurodegeneration 20210702 1
<h4>Background</h4>Human tauopathies including Alzheimer's disease (AD) are characterized by alterations in the post-translational modification (PTM) pattern of Tau, which parallel the formation of insoluble Tau aggregates, neuronal dysfunction and degeneration. While PTMs on aggregated Tau have been studied in detail, much less is known about the modification patterns of soluble Tau. Furthermore, PTMs other than phosphorylation have only come into focus recently and are still understudied. Solu ...[more]
