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TMEM-98 bioID proximity labelling interactome

ABSTRACT: Investigation into the protein-protein interactome of TMEM-98 in humans

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jimi Wills

LAB HEAD: Ian Jackson

PROVIDER: PXD017091 | Pride | 2020-03-19

REPOSITORIES: Pride

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The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification.

Cross Sally H SH Mckie Lisa L Hurd Toby W TW Riley Sam S Wills Jimi J Barnard Alun R AR Young Fiona F MacLaren Robert E RE Jackson Ian J IJ

PLoS genetics 20200401 4

The precise control of eye size is essential for normal vision. TMEM98 is a highly conserved and widely expressed gene which appears to be involved in eye size regulation. Mutations in human TMEM98 are found in patients with nanophthalmos (very small eyes) and variants near the gene are associated in population studies with myopia and increased eye size. As complete loss of function mutations in mouse Tmem98 result in perinatal lethality, we produced mice deficient for Tmem98 in the retinal pigm ...[more]

PMID: 32236127

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