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Synaptamide activates the adhesion GPCR GPR110 through conformational changes induced by GAIN domain binding

ABSTRACT: Ligand-induced conformational changes of GPR110 in cells probed by chemical cross-linking and mass specrtometry

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Bill Huang

LAB HEAD: Hee-Yong Kim

PROVIDER: PXD017128 | Pride | 2020-05-27

REPOSITORIES: Pride

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Synaptamide activates the adhesion GPCR GPR110 (ADGRF1) through GAIN domain binding.

Huang Bill X BX Hu Xin X Kwon Heung-Sun HS Fu Cheng C Lee Ji-Won JW Southall Noel N Marugan Juan J Kim Hee-Yong HY

Communications biology 20200306 1

Adhesion G protein-coupled receptors (aGPCR) are characterized by a large extracellular region containing a conserved GPCR-autoproteolysis-inducing (GAIN) domain. Despite their relevance to several disease conditions, we do not understand the molecular mechanism by which aGPCRs are physiologically activated. GPR110 (ADGRF1) was recently deorphanized as the functional receptor of N-docosahexaenoylethanolamine (synaptamide), a potent synaptogenic metabolite of docosahexaenoic acid. Thus far, synap ...[more]

PMID: 32144388

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